Jean-Lucien Rouleau, MD has been recognized worldwide for his transformative contributions to cardiology, including translational scientific work in ventricular function, post-infarction ventricular remodelling, and neurohormonal activation. His leadership in clinical research culminated in the development of the life-saving medication sacubitril/valsartan, now routinely used to treat patients with chronic heart failure. As Director of the Institute of Circulatory and Respiratory Health, Dr. Rouleau laid the groundwork for the Strategy for Patient Oriented Research (SPOR), and helped establish networks focusing on respiration, sleep and circadian rhythm, stroke, atrial fibrillation, vascular health and coagulation. As Dean of the Faculty of Medicine, Université de Montréal, he initiated development of a delocalized campus that resolved the lack of needed health care professionals in an underserved region; and championed the development of a patient-partner-public approach to health care education. As a researcher, author, educator, and administrator, Dr. Rouleau has made lasting contributions ranging from medications to health care networks, from medical facilities to improved medical policies and practices. His ongoing service to the cause of accessible and effective public health care now includes a five-year, multi-million dollar grant to lead a nationwide Canada Heart Failure Network.